PTK2 CLIA Kit for Chicken(Gallus gallus) | EIAab.comPTK2 CLIA Kit for Chicken(Gallus gallus)

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PTK2 (Gene name),

Focal adhesion kinase 1 (Protein name ), FAK1_CHICK from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PTK2(FAK;FAK1);

Protein name:

Focal adhesion kinase 1(FADK 1);

Alternative:

pp125FAK;Protein-tyrosine kinase 2(FRNK);pp125FAK;p125FAK;

Organism:

Chicken (Gallus gallus).

General Annotation

Sub Unit:

Interacts with GRB7.

Function:

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Subcellular Location:

Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.

Protein Attributes:

Sequence length:

1053

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1053:

RPH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Gga.15614

String:

Q00944

KEGG:

gga:396416

SMR:

Q00944

UniGene:

Gga.42870

Pfam:

PF00373

Uniprot:

Q00944

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ELISA Kit for Chicken FADK 1

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E1178c

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ELISA Kit for Chicken FADK 1

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E1178h

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ELISA Kit for Chicken FADK 1

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E1178r

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ELISA Kit for Chicken FADK 1

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E1178m

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96T

CLIA Kit for Chicken FADK 1

Cat.:

U1178h

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96T

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CLIA Kit for Chicken FADK 1

Cat.:

U1178c

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96T

CLIA Kit for Chicken FADK 1

Cat.:

U1178r

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96T

CLIA Kit for Chicken FADK 1

Cat.:

U1178m

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96T

Polyclonal Antibody for Chicken FADK 1

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P1178Rb-m

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40ug/0.2ml

Polyclonal Antibody for Chicken FADK 1

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P1178Rb-r

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Polyclonal Antibody for Chicken FADK 1

Cat.:

P1178Rb-h

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40ug/0.2ml

Monoclonal Antibody for Chicken FADK 1

Protein for Chicken FADK 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions."
Schaller M.D. , Borgman C.A. , Cobb B.S. , Vines R.R. , Reynolds A.B. , Parsons J.T.
Proc. Natl. Acad. Sci. U.S.A.89:5192-5196(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-1053 (ISOFORM 1)
tissue: Embryo.
2.

"Chicken and mouse focal adhesion kinases are similar in structure at their amino termini."
Devor B.B. , Zhang X. , Patel S.K. , Polte T.R. , Hanks S.K.
Biochem. Biophys. Res. Commun.190:1084-1089(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-63 (ISOFORM 1)
tissue: Embryo.
3.

"Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK."
Schaller M.D. , Borgman C.A. , Parsons J.T.
Mol. Cell. Biol.13:785-791(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PROMOTER USAGE;IDENTIFICATION OF ISOFORM 2;PHOSPHORYLATION;SUBCELLULAR LOCATION
4.

"An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase."
Hildebrand J.D. , Taylor J.M. , Parsons J.T.
Mol. Cell. Biol.16:3169-3178(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGAP26
5.

"Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration."
Reiske H.R. , Kao S.C. , Cary L.A. , Guan J.L. , Lai J.F. , Chen H.C.
J. Biol. Chem.274:12361-12366(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND SRC;MUTAGENESIS OF ASP-395
6.

"Association of Grb7 with phosphoinositides and its role in the regulation of cell migration."
Shen T.L. , Han D.C. , Guan J.L.
J. Biol. Chem.277:29069-29077(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7
7.

"Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397."
Leu T.H. , Maa M.C.
Oncogene21:6992-7000(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-397; TYR-576 AND TYR-863
8.

"Focal adhesion kinase in netrin-1 signaling."
Ren X.R. , Ming G.L. , Xie Y. , Hong Y. , Sun D.M. , Zhao Z.Q. , Feng Z. , Wang Q. , Shim S. , Chen Z.F. , Song H.J. , Mei L. , Xiong W.C.
Nat. Neurosci.7:1204-1212(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DCC
9.

"Activation of FAK and Src are receptor-proximal events required for netrin signaling."
Li W. , Lee J. , Vikis H.G. , Lee S.H. , Liu G. , Aurandt J. , Shen T.L. , Fearon E.R. , Guan J.L. , Han M. , Rao Y. , Hong K. , Guan K.L.
Nat. Neurosci.7:1213-1221(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DCC
10.

"Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction."
Liu G. , Beggs H. , Jurgensen C. , Park H.T. , Tang H. , Gorski J. , Jones K.R. , Reichardt L.F. , Wu J. , Rao Y.
Nat. Neurosci.7:1222-1232(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex."
Serrels B. , Serrels A. , Brunton V.G. , Holt M. , McLean G.W. , Gray C.H. , Jones G.E. , Frame M.C.
Nat. Cell Biol.9:1046-1056(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THE ARP2/3 COMPLEX
12.

"FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells."
Koshman Y.E. , Kim T. , Chu M. , Engman S.J. , Iyengar R. , Robia S.L. , Samarel A.M.
Arterioscler. Thromb. Vasc. Biol.30:2226-2233(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130Cas Binding."
Koshman Y.E. , Chu M. , Engman S.J. , Kim T. , Iyengar R. , Robia S.L. , Samarel A.M.
Arterioscler. Thromb. Vasc. Biol.31:2432-2440(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy."
Chu M. , Iyengar R. , Koshman Y.E. , Kim T. , Russell B. , Martin J.L. , Heroux A.L. , Robia S.L. , Samarel A.M.
Cardiovasc. Res.92:409-419(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-911;FUNCTION
15.

"Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase."
Liu G. , Guibao C.D. , Zheng J.
Mol. Cell. Biol.22:2751-2760(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 916-1053
16.

"NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model."
Gao G. , Prutzman K.C. , King M.L. , Scheswohl D.M. , DeRose E.F. , London R.E. , Schaller M.D. , Campbell S.L.
J. Biol. Chem.279:8441-8451(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 920-1053 IN COMPLEX WITH PXN;INTERACTION WITH PXN
17.

"The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation."
Prutzman K.C. , Gao G. , King M.L. , Iyer V.V. , Mueller G.A. , Schaller M.D. , Campbell S.L.
Structure12:881-891(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 920-1053
18.

"Crystal structure of the FERM domain of focal adhesion kinase."
Ceccarelli D.F. , Song H.K. , Poy F. , Schaller M.D. , Eck M.J.
J. Biol. Chem.281:252-259(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 31-405
19.

"Structural basis for the autoinhibition of focal adhesion kinase."
Lietha D. , Cai X. , Ceccarelli D.F. , Li Y. , Schaller M.D. , Eck M.J.
Cell129:1177-1187(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 411-686 IN COMPLEXES WITH STAUROSPORINE AND ATP ANALOG;ENZYME REGULATION;PHOSPHORYLATION AT TYR-576 AND TYR-577
20.

"Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation."
Lietha D. , Eck M.J.
PLoS ONE3:E3800-E3800(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 411-686 IN COMPLEX WITH TAE226

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